CJC-1295 no DAC: four substitutions explained

The name contains a negative, and that negative decides which substance is in the vial. CJC-1295 exists with and without DAC; they are two different compounds, each with its own identification number.

Twenty-nine residues, four of them substituted

The specification table lists this substance as Modified GRF (1–29). That means the first twenty-nine amino acids of growth hormone-releasing hormone, with four positions exchanged for variants that enzymes attack less readily. This is why the same substance also goes by the name Mod GRF 1–29.

The molecular formula is C₁₅₂H₂₅₂N₄₄O₄₂, the molar mass 3367.90 g/mol and the CAS number 863288-34-0. All of these figures are on the product page.

The unmodified version of the same sequence is Sermorelin. The two are only around ten grams per mole apart; how mass measurement and chromatography tell molecules apart is covered in HPLC and mass spectrometry.

Why "no DAC" is part of the name

DAC stands for Drug Affinity Complex, an additional group that binds the molecule to albumin. The version with DAC is therefore a different compound, with a different mass and its own CAS number.

When checking a certificate, that means matching the number 863288-34-0, not the name. Reading only "CJC-1295" does not tell you which of the two variants is in front of you, but the masses differ by enough for a certificate to give it away.

Seven certificates from two lot sizes

The certificate library holds seven certificates of analysis for this substance, more than for any other item in this catalogue except GHK-Cu. They come from six 5 mg lots and one 2 mg lot; the vial listed here is 5 mg.

Four of the seven report a measured purity above 99.8%. The other three give 99.26% (lot 2024198), 98.17% (lot 2025247, 2 mg) and 97.677% (lot 237168). This shop does not state a blanket minimum purity; what counts is the measured value in the certificate for each lot. Each certificate applies to its own lot, and what else to look for is explained in How to read a certificate of analysis.

Twenty-nine residues take a lot of work

Twenty-eight coupling steps in solid-phase synthesis come close to what Retatrutide demands with its thirty-nine residues. That the certificates still regularly report above 99.8% is the genuinely notable fact about this substance.

Purity should not be confused with peptide content: that describes what share of the weighed material is pure peptide, and it is regularly lower because of counterions and residual moisture.

Also available as a ready-made blend

Together with Ipamorelin, this substance is in the catalogue as a ready-made blend, CJC-1295 no DAC + ipamorelin. The two belong to different classes: Ipamorelin acts at the ghrelin receptor, this substance on the GHRH side.

For blends the specification applies to each component; there is no combined purity value, as Research blends and their certificates explains, and the library holds no report for this blend; the only blend report there is for BPC-157 + TB-500, which gives no numerical purity figure. The product is supplied as a lyophilised powder that goes into solution with bacteriostatic water; the glossary entries on reconstitution and concentration explain the terms.

In brief

Twenty-nine residues with four substitutions, 3367.90 g/mol, CAS 863288-34-0, seven certificates of analysis from 5 mg and 2 mg lots. The blend partner is covered in Ipamorelin explained.

Questions

What is the difference between CJC-1295 with and without DAC?

The version with DAC carries an additional group that binds the molecule to albumin. They are two different compounds with their own CAS numbers; the one listed here is the version without DAC, 863288-34-0.

Is Mod GRF 1–29 the same thing?

Yes, it is a second common name for the same substance. When checking a certificate, the CAS number counts, not the name.

Why does one certificate come from a 2 mg lot?

Because the substance has been filled in different sizes over time. Each certificate applies to the lot it comes from; the vial sold here is 5 mg.